Insulin Secretion from Toadfish Islet Tissue Stimulated by Pyridine Nucleotides

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Science  11 Oct 1968:
Vol. 162, Issue 3850, pp. 283-284
DOI: 10.1126/science.162.3850.283


The addition of glucose stimulated release of insulin from the isolated islet tissue of the toadfish incubated in vitro. Reduced nicotinamide-adenine dinucleotide also stimulated insulin release, whereas the oxidized form had no effect. Both oxidized and reduced nicotinamide-adenine dinucleatide phosphate stimulated insulin release, but the reduced form was significantly more effective.

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