Conformation of Blood-Group and Virus Receptor Glycoproteins from Red Cells and Secretions

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Science  18 Oct 1968:
Vol. 162, Issue 3851, pp. 365-367
DOI: 10.1126/science.162.3851.365


Optical rotatory dispersion of human blood-group and virus receptor glycoproteins from erythrocytes and secretions was studied in the far-ultraviolet. Erythrocyte membrane blood-group glycoproteins, with potent virus receptor activities, contained significant alpha-helical and extended beta conformations, whereas the glycoproteins of secretions were largely disordered. These conclusions were supported by determination of the Moffitt constants (b0) and by measurements of circular dichroism.

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