Chemical Sensing: An Approach to Biological Molecular Mechaisms Using Difference Spectroscopy

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Science  25 Oct 1968:
Vol. 162, Issue 3852, pp. 452-454
DOI: 10.1126/science.162.3852.452


Stimulation of preparations of rabbit olfactory epithelium with aqueous solutions containing the odorants linalool or inalyl isobutyrate, or both, initiates molecular changes that can be monitored by a specific decrease in absorbance at 267 nanometers. This change in absorbance appears to be associated with a change in macromolecular conformation which is initiated by formation of a complex involving the stimulant molecules.

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