Evoked Release of Norepinephrine and Serotonin from Brain Slices: Inhibition by Lithium

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Science  25 Oct 1968:
Vol. 162, Issue 3852, pp. 466-467
DOI: 10.1126/science.162.3852.466


Slices of mammalian brain accumulate H3-norepinephrine and H3-serotonin when incubated in a physiologic medium containing these tritiated monoamines. When these tissues are subjected to mild electrical stimulation of short duration, which is associated with depolarization of nerve membranes, a striking increase in the rate of efflux of the exogenous labeled monoamines occurs. Stimulation-induced release of both labeled monoamines is diminished by the presence of lithium ions in the perfusing medium; related monovalent cations had no such effect. Evoked release from slices of brain from animals treated intraperitoneally with lithium chloride for 3 days was also reduced.

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