Erythromycin-Resistant Mutant of Escherichia coli with Altered Ribosomal Protein Component

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Science  01 Nov 1968:
Vol. 162, Issue 3853, pp. 576-578
DOI: 10.1126/science.162.3853.576


Erythromycin combines with 50S ribosomal subunit of an erythromycin-sensitive Escherichia coli (strain Q13), while ribosomes from an erythromycin-resistant mutant from this strain have little affinity for the antibiotic. A protein component of the 50S subunit of the mutant strain is distinct from that of the parent Q13 strain.

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