Histone Phosphorylation: Stimulation by Adenosine 3',5'-Monophosphate

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Science  01 Nov 1968:
Vol. 162, Issue 3853, pp. 579-580
DOI: 10.1126/science.162.3853.579


Adenosine cyclic 3',5'-monophosphate at a concentration of 10-7M causes a four-to sixfold increase in the rate of histone phosphorylation catalyzed by a liver enzyme preparation. This observation suggests a mechanism for the induction of RNA synthesis by those hormones that cause increases in the concentration of cyclic AMP.

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