Noncycling Tumor Cells: Mitogenic Response to Antilymphocytic Serum

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Science  08 Nov 1968:
Vol. 162, Issue 3854, pp. 698-699
DOI: 10.1126/science.162.3854.698


After continuous labeling with tritiated thymidine for a period several times the cell generation time, some ELD ascites cells remained unlabeled. Despite continued exposure to tritiated thymidine, unlabeled mitoses appeared promptly after administration of mouse antilymphocytic serum. Immunosuppression released some noncycling G2 tumor cells into mitosis.

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