Genetic Polymorphism of C'3(β1c-Globuiin) in Human Serum

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Science  22 Nov 1968:
Vol. 162, Issue 3856, pp. 905-907
DOI: 10.1126/science.162.3856.905


Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C31, 0.21; C32, 0.77; C33, ∼0.01; and C34, ∼0.004.

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