Chemical Carcinogenesis: Persistence of Bound Forms of 2-Fluorenylacetamide

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Science  22 Nov 1968:
Vol. 162, Issue 3856, pp. 907-908
DOI: 10.1126/science.162.3856.907


The persistent binding of metabolites of hepatic carcinogen, 2-fluorenylacetamide, to glycogen and to DNA in a new population of liver cells, hyperplastic nodules, and to glycogen in liver cancer cells weeks to months after the carcinogen was removed from the animals' diet is indicated by spectrophotometric, chromatographic, and mass spectrographic data. This persistence of binding does not appear to occur in the nonhyperplastic or nonneoplastic liver surrounding the nodules or the cancer.

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