Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding

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Science  22 Nov 1968:
Vol. 162, Issue 3856, pp. 917-918
DOI: 10.1126/science.162.3856.917


Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase. In vitro, it has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol. The existence of this microsomal ethanol-oxidizing system may explain ultrastructural, pharmacological, and biochemical effects of ethanol.

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