Activation of Hageman Factor by L-Homocystine

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Science  29 Nov 1968:
Vol. 162, Issue 3857, pp. 1007-1009
DOI: 10.1126/science.162.3857.1007-a


L-Homocystine activates Hageman factor, as demonstrated by its capacity to initiate clotting and to induce the evolution of plasma kinins. Perhaps, strategically located deposits of this amino acid are responsible for the unusual frequency of thrombosis in patients with homocystinuria.

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