Basis for the Acquaisition of Malignant Potential by Mouse Cells Cultivated in vitro

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Science  29 Nov 1968:
Vol. 162, Issue 3857, pp. 1024-1026
DOI: 10.1126/science.162.3857.1024


Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.

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