Hemin: An Inhibitor of Erythroid Cell Ribonuclease

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Science  13 Dec 1968:
Vol. 162, Issue 3859, pp. 1287
DOI: 10.1126/science.162.3859.1287


Hemin, in concentrations which stimulate protein synthesis and stabilize polyribosomes in reticulocytes, is a potent inhibitor of ribonuclease activity in the erythroid cell. This may offer a partial explanation for the way in which hemin acts to accelerate globin synthesis and thus synchronize the synthesis of hemin and globin in the maturing erythroid cell.