Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine

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Science  13 Dec 1968:
Vol. 162, Issue 3859, pp. 1290-1292
DOI: 10.1126/science.162.3859.1290


Tolerance and physical dependence development to morphine in mice can be prevented by concomitant administration of cycloheximide. The fact that the rate of synthesis of brain 5-hydroxytryptamine (5HT) increases with tolerance to morphine suggests that the protein involved may be associated with 5HT synthesis. Inhibition of this synthesis with p-chlorophenylalanine markedly decreases tolerance and physical dependence development to morphine.

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