Warfarin Treatment of Mice Bearing Autochthonous Tumors: Effect on Spontaneous Metastases

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Science  27 Dec 1968:
Vol. 162, Issue 3861, pp. 1493-1494
DOI: 10.1126/science.162.3861.1493


Long-term oral administration of sodium warfarin significantly reduced the incidence of spontaneous metastases in the lungs from 83 percent in controls to 8 percent in treated C57/BL/6N mice. The size and weight of primary tumors in mice treated with warfarin were less than in control mice. Length of survival was unaffected.

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