lmmunologic Enhancement of Tumor Xenografts by Pepsin-Degraded Immunoglobulin

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Science  27 Dec 1968:
Vol. 162, Issue 3861, pp. 1494-1495
DOI: 10.1126/science.162.3861.1494


The serums from guinea pigs previously injected with mouse Ehrlich ascites tumor cells were fractionated to obtain γ2-immunoglobulin. This immunoglobulin was degraded with pepsin to obtain an F(ab')2 fragment. Fresh tumor cells were incubated with immunoglobulin or the fragment and injected into normal guinea pigs. The growth of these cells as tumor xenografts was inhibited by the γ2-immunoglobulin and enhanced by the F(ab')2 fragment. Similar incubation of tumor cells with normal guinea pig γ2-globulin or its derived F(ab')2 fragment did not alter subsequent tumor growth.

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