Separation of Cellular from Extracellular Controls of Drinking in Rats by Frontal Brain Damage

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Science  27 Dec 1968:
Vol. 162, Issue 3861, pp. 1501-1503
DOI: 10.1126/science.162.3861.1501


Rats that had undergone removal of the frontal portion of the brain, including the olfactory bulbs, did not drink, or drank less than controls, when subjected to cellular dehydration. These same animals drank normally in response to extracellular volume reduction. Rats from which only the olfactory bulbs had been removed drank normally in both tests. An essential part of the neurological system mediating drinking produced by cellular dehydration, but not by volume reduction, therefore lies within the frontal cortex or immediate subcortical tissue.

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