Macroglobulin Structure: Homology of Mu and Gamma Heavy Chains of Human Immunoglobulins

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Science  03 Jan 1969:
Vol. 163, Issue 3862, pp. 75-78
DOI: 10.1126/science.163.3862.75


The amino acid sequence of fragments obtained by cyanogen bromide cleavage of the mu-chain of a human γM-globulin is homologous to the NH2-terminal sequences of the gamma-chain of human and rabbit γG-globulins and is related to that of human light chains. This supports the hypothesis that light and heavy chains evolved from a common ancestral gene.

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