Hemophilia: Role of Organ Homografts

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Science  10 Jan 1969:
Vol. 163, Issue 3863, pp. 188-190
DOI: 10.1126/science.163.3863.188


The concentration of factor VIII and partial thromboplastin times became normal and have remained normal for 140 days after orthotopic tranplantation of a normal liver to a hemophilic dog. Transplantation of a normal spleen into a hemophilic recipient did not result in a significant increase in factor VIII although the splenic graft was viable for at least 47 days. Transplantation of normal marrow to a lethally irradiated hemophilic dog did not result in an increase in factor VIII during 34 days of observation.

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