Amino Acid Incorporation into Rat Brain Proteins during Spreading Cortical Depression

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Science  24 Jan 1969:
Vol. 163, Issue 3865, pp. 393-395
DOI: 10.1126/science.163.3865.393


Unilateral spreading cortical depression was elicited by applying potassium chloride solutions to the dura of conscious, freely moving rats. Incorporation of 3H-leucine into soluble cortical proteins was decreased in the depressed hemisphere relative to the control side, while soluble brainstem proteins from both sides had the same specific activity. Various subfractions of soluble cortical proteins were affected to equal degrees.

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