Secretory Activity and Oncogenicity of a Cell Line (MDCK) Derived from Canine Kidneyand

See allHide authors and affiliations

Science  31 Jan 1969:
Vol. 163, Issue 3866, pp. 472-473
DOI: 10.1126/science.163.3866.472


A cell line (MDCK) of dog kidney origin grows on a glass surface as a mosaic of epithelium with many multicellular hemispherical vesicles. The cells lining the blisters actively secrete into the cyst cavities. Suspensions of these cells injected intravenously in the chick embryo produce brain metastases resembling adenocarcinoma.

Stay Connected to Science