Collagen Has a Discrete Family of Reactive Hydroxylysyl and Lysyl Side-Chain Amino Groups

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Science  07 Feb 1969:
Vol. 163, Issue 3867, pp. 578-579
DOI: 10.1126/science.163.3867.578


Several cross-linking substances which derive from lysine have been isolated from hydrolyzates of collagen and elastin. This observation suggests that certain lysyl side chains exhibiting enhanced reactivity and unique configuration may participate in cross-linking. In native collagen there is a small family of lysyl and hydroxylysyl side chains which exhibit a high propensity of Schiff base formation.

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