Prostaglandin Stimulation of Rat Corticosteroidogenesis

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Science  14 Feb 1969:
Vol. 163, Issue 3868, pp. 691-692
DOI: 10.1126/science.163.3868.691


Prostaglandins and their C20:ω6 fatty acid precursors are present in rat adrenal glands. Small doses of prostaglandins (PGE1, PGE2, or PGF1∞ 1.4 to 2.4 micromolar) increased steroidogenesis in the superfused adrenal glands obtained from hypophysectomized rats. This effect was mimicked in part by both adrenocorticotropin and its postulated intracellular intermediate adenosine 3', 5'-cyclic monophosphate; all three responses were inhibited by cycloheximide.

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