Leukotactic Factor Produced by Sensitized Lymphocytes

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Science  07 Mar 1969:
Vol. 163, Issue 3871, pp. 1079-1081
DOI: 10.1126/science.163.3871.1079


Lymph node lymphocytes obtained from guinea pigs exhibiting delayed hypersensitivity are stimulated in vitro by specific antigen to produce a soluble factor that is chemotactic in vitro for mononuclear macrophages. The material is nondialyzable, relatively heat stable, and elutes from Sephadex G-100 in the fraction containing molecules smaller than immunoglobulins.

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