Chick Interferon: Heterogeneity of Electric Charge

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Science  14 Mar 1969:
Vol. 163, Issue 3872, pp. 1198-1199
DOI: 10.1126/science.163.3872.1198


Chick interferon from allantoic fluid, virus-induced and partly purified, consists of several active components of different charge. The components are separable by elution at different pH values from a carboxymethyl-Sephadex column; they also occupy different pH zones in electrofocusing gradients. Most of the interferon is, however, isoelectric near neutrality.

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