Automated Analysis of Cellular Change in Histological Sections

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Science  14 Mar 1969:
Vol. 163, Issue 3872, pp. 1200
DOI: 10.1126/science.163.3872.1200


An image analysis computer has been used to count and measure goblet cells in the epithelium of the bronchiolar tree of rats exposed to sulfur dioxide vapor. A technique was developed which enabled a bioassay of the irritant effects of the gas.

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