Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility (H-2) Type

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Science  14 Mar 1969:
Vol. 163, Issue 3872, pp. 1207-1208
DOI: 10.1126/science.163.3872.1207


The immune responses of inbred mice to a related series of three synthetic polypeptide antigens are genetically controlled traits which are closely correlated with the genotype for the major histocompatibility (H-2) locus. All strains of the same H-2 type exhibit the same pattern of immune response, independent of the remainder of a given strain's genetic background. There is marked antigen-specific polymorphism between strains of different H-2 types with respect to their patterns of response.

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