Serine Requirement in Leukemic and Normal Blood Cells

See allHide authors and affiliations

Science  28 Mar 1969:
Vol. 163, Issue 3874, pp. 1452-1453
DOI: 10.1126/science.163.3874.1452


In a serine-deficient medium, cells from humangt chronic granulocytic leukemia and normal human bone marrow exhibited a marked inhibition of incorporation of-radioactive precursors of DNA, RNA, and protein into an acid insoluble cell fraction. Normal diploid human fibroblasts did not exhibit inhibition without serine. Chronic granulocytic leukemia and normal marrow cells were essentially unable to synthesize C14-serine from C14-glucose, while human diploid fibroblasts were highly capable of this synthesis.

Stay Connected to Science