Antifungal Steroid Glycoside from Sea Cucumber

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Science  28 Mar 1969:
Vol. 163, Issue 3874, pp. 1462
DOI: 10.1126/science.163.3874.1462


An antifungal steroid glycoside, holotoxin, has been isolated from the sea cucumber Stichopus japonicus (Selenka). In vitro, it exhibits high activity against various fungi, including vegetable pathogens, but has scarcely any activity against Gram-positive and Gram-negative bacteria and mycobacteria in vitro.

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