Acute Axonal Dystrophy Caused by Fluorocitrate: The Role of Mitochondrial Swelling

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Science  18 Apr 1969:
Vol. 164, Issue 3877, pp. 310-312
DOI: 10.1126/science.164.3877.310


Fluorocitrate, a Krebs cycle inhibitor, induices neurons to rapidly expel multitudinous lysosomes, mitochondria, and other cytoplasmic constituents into their axons. After convulsive seizures commence, spectacular axonal balloons develop owing to obstruction of axonal flow by "log jams" of extruded organelles. A swelling of neuronal mitochondria is apparently responsible for the disgorgement of cytoplasmic material into axons.

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