Potassium, Corticosterone, and Adrenocorticotropic Hormone Release in vitro

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Science  25 Apr 1969:
Vol. 164, Issue 3878, pp. 426
DOI: 10.1126/science.164.3878.426


Incubation of rat adenohypophyses in a high concentration of potassium increases adrenocorticotropic hormone release. This increased release is suppressed by the addition of corticosterone to the incubating medium. Our findings are consistent with a process of "stimulus-secretion coupling" proposed for other glands and suggest that corticosterone may operate directly on the adenohypophysial cell membrane to inhibit releasing mechanisms.

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