Glucagon-Sensitive Adenyl Cylase in Plasma Membrane of Hepatic Parenchymal Cells

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Science  02 May 1969:
Vol. 164, Issue 3879, pp. 566-567
DOI: 10.1126/science.164.3879.566


The plasma membrane of hepatic parenchymal cells contains an adenyl cyclase system that is stimulated by glucagon. Adrenocorticotropin and epinephrine do not stimulate this adenyl cyclase, and very little cyclic phospho-diesterase activity is present in the membrane. These findings support the concept that glucagon exerts its regulatory action in the liver by stimulating adenyl cyclase activity in the plasma membrane.

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