Hallucinogen-Tranquilizer Interaction: Its Nature

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Science  02 May 1969:
Vol. 164, Issue 3879, pp. 569-571
DOI: 10.1126/science.164.3879.569


Study of the competition between hallucinogens and tranquilizers at cerebral synapses and on behavior in various species of animals indicates a continuum of effects from protection to dominance of tranquilizer toxicity as the dose of tranquilizer increases. Data on cat and monkey behavior, supplementing that on the rat, show that it is possible to arrive at a tranquilizer dose that can aggravate instead of protect, in accord with the competitive inhibitory nature of the interaction of hallucinogen and tranquilizer.

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