Lysergic Acid Diethylamide: Effects on the Developing Mouse Lens

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Science  02 May 1969:
Vol. 164, Issue 3879, pp. 574-575
DOI: 10.1126/science.164.3879.574


High doses (5 x 10-6 gram) of LSD-25 given to Swiss-Webster females on gestation days 6, 7, 8, or 9 caused a high incidence of anterior subcapsular lens abnormalities. Accompanying this, the lens epithelium was often hyperplastic, and the lens bow was widened posteriorly in a fashion similar to cataracts induced by x-radiation. Confirmation of this effect of LSD-25 was obtained by a (duplicate) experiment 1 year after the observations reported.

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