Encephalitogenic Protein: Structure

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Science  02 May 1969:
Vol. 164, Issue 3879, pp. 577-580
DOI: 10.1126/science.164.3879.577


Amino acid sequences of encephalitogenic proteins from bovine cord and rabbit brain are reported. The bovine protein contains 45 residues. The rabbit protein is identical except for two isopolar substitutions, a dipeptide and amino acid deletion. Analysis of this protein and a 140-residue myelin basic protein indicates that the smaller protein is a portion of the larger encephalitogen. The larger myelin protein contains at least two encephalitogenic sites.

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