Dye-Sensitized Photooxidation of the Escherichia coli Ribosome

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Science  02 May 1969:
Vol. 164, Issue 3879, pp. 583-584
DOI: 10.1126/science.164.3879.583


Chemical modification of ribosomes from Escherichia coli by oxidation in the presence of selected photosensitizing dyes causes a rapid loss of their amino acid-incorporating ability. By comparing the efficiency of dyes that sensitize the photooxidation of either guanine in ribonucleic acid or amino acid residues in proteins, inactivation of one or more functional ribosomal proteins is inferred.

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