L-Tyrosine-3, 5-3H Assay for Tyrosinase Development in Skin of Newborn Hamsters

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Science  16 May 1969:
Vol. 164, Issue 3881, pp. 838-839
DOI: 10.1126/science.164.3881.838


Tyrosinase in hamster skin, measured by the production of 3HOH from L-tyrosine-3,5-3H, increases about sevenfold in specific activity from the 14-day fetus to day 6 of life. Albino hamsters exhibit no activity, but enzyme is present in the ventral (white) areas of the Syrian hamster. 3,4-Dihydroxy-L-phenylalanine is required as a cosubstrate.

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