Inv(1) Allotype: Effect of Immunoglobulin G Heavy Chain Subtype on Its Expression

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Science  30 May 1969:
Vol. 164, Issue 3883, pp. 1072-1073
DOI: 10.1126/science.164.3883.1072


More protein is required to detect the Inv(1) antigen carried in the light chain of immunoglobulin G molecules when the light chain is combined with a γ2 heavy chain than when it is combined with a γ1 or γ3 heavy chain. One of the four γ2 heavy chains used in the experiment, however, was as efficient as the γ1 and γ3 chains, indicating that there may be two subtypes of γ2. Inv(1) was more easily detected in one of the two light chains used in the experiment. This difference may be associated with the subtypes of the kappa chain derived from studies of the variable portion of the chain.

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