Antiserum to Lymphocytes and Procarbazine Compared as Immunosuppressants in Mice

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Science  30 May 1969:
Vol. 164, Issue 3883, pp. 1082-1083
DOI: 10.1126/science.164.3883.1082


As an immunosuppressant procarbazine was as potent as an antiserum to lymphocytes in mice. Both agents significantly prolonged survivals of skin allografts by 4 to 6 weeks. At the maximum tolerated dosage, procarbazine suppressed both circulating hemagglutinins to sheep erythrocytes and plaque-forming cells in the spleen. The antiserum to lymphocytes reduced the numbers of circulating hemagglutinins and plaque-forming cells by 94 percent. Procarbazine was administered to mice for 3 weeks before their exposure to antigen. Exposure for only 9 days, commencing 48 hours before injection of sheep erythrocytes, was less effective in suppressing the titers of hemagglutinins.

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