Protective Effect of Antilymphocyte Serum on Mice Infected with Plasmodium berghei

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Science  20 Jun 1969:
Vol. 164, Issue 3886, pp. 1423-1425
DOI: 10.1126/science.164.3886.1423


Rabbit antiserum to mouse lymphocytes prolonged the survival of mice infected with Plasmodium berghei. Since antilymphocyte serum has a well-defined, potent immunosuppressive effect, the immune response of the host to the parasite actually may contribute to the death of the animal with an acute malarial infection.

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