Generation of Adrenergic and Cholinergic Potentials in Sympathetic Ganglion Cells

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Science  27 Jun 1969:
Vol. 164, Issue 3887, pp. 1530-1532
DOI: 10.1126/science.164.3887.1530


Norepinephrine elicited a hyperpolarizing response, and acetylcholine (during nicotinic blockade) elicited a depolarizing one. Both responses showed no increase in membrane conductance. The norepinephrine response was suppressed by initial depolarization; the acetylcholine response (frog cells); by hyperpolarization. These neurotransmitters apparently can activate electrogenic mechanisms which do not involve movement of ions down their electrochemical gradients.

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