Blood-Brain Barrier: Evidence for Active Cation Transport between Blood and the Extraceliular Fluid of Brain

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Science  04 Jul 1969:
Vol. 165, Issue 3888, pp. 81-83
DOI: 10.1126/science.165.3888.81


The concentration gradients of Mg++ and K+ in the cerebrospinal fluid system indicate that the (Mg++) is higher and the (K+) is lower in the extra-cellular fluid of the cerebral cortex than the concentrations of these cations in either plasma-dialysate or cisternal fluid. Such cation distribution demonstrates the existence of an active transport process across the blood-brain barrier.

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