Cyclophosphamide: Effect on Experimental Allergic Encephalomyelitis in Lewis Rats

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Science  11 Jul 1969:
Vol. 165, Issue 3889, pp. 191-192
DOI: 10.1126/science.165.3889.191


Lewis rats sensitized to spinal cord in adjuvant and exhibiting advanced clinical paralytic signs of experimental allergic encephalomyelitis were treated with cyclophosphamide (5 milligrams per kilogram) daily. Of 30 treated animals, 21 recovered rapidly and appeared clinically well within 7 to 12 days. This immunosuppressive agent may prove therapeutically useful in the treatment of autoimmune diseases.

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