Indole(ethyl)amine N-Methyltransferase in the Brain

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Science  01 Aug 1969:
Vol. 165, Issue 3892, pp. 492-493
DOI: 10.1126/science.165.3892.492


An enzyme which N-methylates various indole(ethyl)amine substrates was isolated from brain, separated from the pituitary and the pineal glands. It appeared localized in the supernatant and synaptosomal areas after discontinuous sucrose-gradient ultracentrifugation. This is the first demonstration of the enzyme in brain.

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