Induction in vitro of Microtubular Crystals by Vinca Alkaloids

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Science  01 Aug 1969:
Vol. 165, Issue 3892, pp. 495-496
DOI: 10.1126/science.165.3892.495


The addition of vinblastine or vincristine to solutions of pure microtubule protein or to supernatants from high-speed centrifugation of rabbit-brain homogenates results in the formation of a fine precipitate. Examination of this precipitate by electron microscopy reveals ordered structures with areas of ladder-like configuration.

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