Estradiol: Specific Binding by Pituitary Nuclear Fraction in vitro

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Science  01 Aug 1969:
Vol. 165, Issue 3892, pp. 496-498
DOI: 10.1126/science.165.3892.496


The nuclear fraction of a homogenate of anterior pituitary has a marked binding affinity for estradiol but not for other hormonal steroids. Characteristics of the uptake of estradiol by pituitary nuclear fraction are like those reported for the uterus. Study in vitro will be useful in elucidating how direct estrogen feedback control of anterior pituitary function is mediated.

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