Vinblastine-Induced Precipitation of Microtubule Protein

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Science  01 Aug 1969:
Vol. 165, Issue 3892, pp. 498-499
DOI: 10.1126/science.165.3892.498


Vinblastine quantitatively precipitates a protein from supernatants obtained from high-speed centrifugation of homogenates of HeLa cells and of pig brain. This protein migrates as a single band on gel electrophoresis, has a mobility identical to that of purified microtubule protein, and-like microtubule protein-binds colchicine. The precipitation is partially inhibited by 0.9 percent NaCl.

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