Turbidity, Birefringence, and Fluorescence Changes in Skeletal Muscle Coincident with the Action Potential

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Science  08 Aug 1969:
Vol. 165, Issue 3893, pp. 608-609
DOI: 10.1126/science.165.3893.608


Electrical stimulation of frog striated muscle was found to prduce trasient changes in turbidity. birefringence, and fluorescence (of fibers stained with pyronine B). The initial phase of these optical changes Was coinicident with the action potential. These findings suggest that there is a macromolecular conformational change in muscle membrane during excitation.

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