Epinephrine Metabolism in Mammalian Brain after Intravenous and Intraventricular Administration

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Science  08 Aug 1969:
Vol. 165, Issue 3893, pp. 616-617
DOI: 10.1126/science.165.3893.616


Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation.

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