Viral Infection Across Species Barriers: Reversible Alteration of Murine Sarcoma Virus for Growth in Cat Cells

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Science  15 Aug 1969:
Vol. 165, Issue 3894, pp. 714-716
DOI: 10.1126/science.165.3894.714


Infection of cat embryo cells by a centrifugally induced aggregate of murine sarcoma virus and feline leukemia virus gave rise to a defective, focus-forming virus which propagated in cat cells, but not in mouse cells. This virus, apparently enveloped with a feline leukemia virus coat, was later subjected to aggregation with murine leukemia virus, whereupon it regained the capacity for growth in mouse cells.

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